crenata Hochst. Dalechamps and Bauhin state Musa's recommendation of the herb in warm water as beneficial to those sighing and breathing with difficulty; while the leaves in honey help consumptives, especially those who cough up purulent matter. Ley’s group have isolated from Scutellaria woronowii (Juz.) Larval susceptibility of Ajuga remota against anopheline and culicine mosquitos. Using the antifeedant index (AI = [(C − T)/(C + T)]% where C and T are the weight of the control and test disks eaten, respectively), at 100 ppm Jodrellin B had an AI of 100, Jodrellin A had an AI of 92, and clerodin had an AI of 74. 2007). Contextual translation of "ajuga" into English. Its two known isolates ajugarin-1 and ergosterol-5,8-endoperoxide and a new isolate 8- O -acetylharpagide were evaluated for their in vitro antiplasmodial activity. =*Ajuga remota var. Another interesting feature of terpenes described in this chapter is their compelling ability, within a “trophic window zone”, to induce the sprouting of neurites and even the growth of neurons, thus suggesting a possibility to put an end to ALS, to treat spinal injuries and to replenish neuronal population in loci of neurodegeneration. Strychnos henningsii Gilg, Ajuga remota Benth., Warbugia ugandensis Sprague and Olea europaea L. The first three species are used in all the five districts while the others are restricted in some of the districts. But there are a few situations i… ex Vatke =Ajuga bracteosa var. ex Vatke : Synonym(s) Heterotypic =Ajuga remota Benth. Identifying lead molecules from natural products might help to find better anti-malarial drugs, since those obtained from natural sources are still effective against malarial parasites. A large number of compounds have already been isolated from A. remota, including ergosterol-5,8-endoperoxide (6), ajugarin-I (1), 8-O-acetylharpagide (5) and several phytoecdysteroids. ‘During the autumn, the foliage of tricolour sage and ajuga becomes burnished with bronze, plum, and garnet.’ ‘Other options include ajuga and low-growing herbs such as thyme.’ ‘They left wide strips between large slabs of Arizona flagstone for planting, and filled the spaces with giant ajuga and Lamium maculatum ‘White Nancy’.’ It is also used in Morocco to treat other illnesses such as rheumatic pains, hypertension, cardiovascular disorders, ocular infection, rheumatism, allergy, cancer, renal diseases, and digestive disorders (El Rhaffari and Zaid, 2002; El Amrani et al., 2010; Ghourri et al., 2013; Benkhnigue et al., 2014; Jamila and Mostafa, 2014; Hachi et al., 2015; Orch et al., 2015; Slimani et al., 2016; Youbi et al., 2016; Bouyahya et al., 2017). Copyright © 2020 Elsevier B.V. or its licensors or contributors. In vitro pharmacological studies have been conducted on constituents of A. remota of which some of them displayed a concentration-dependent inhibition of chloroquine-sensitive and -resistant Plasmodium falciparum and Mycobacterium tuberculosis. canescens (Benth.)Cufod. The comparative antifeedant effects of several nonalkaloidal and alkaloidal ryanoids supported the hypothesis of a ryanodol-specific mode of action in insects.64,67 The insect-selective insecticidal and antifeedant effects of ryanodanes hold a promising future for their use as biopesticides. Pharmacological studies proving the antidiabetic effect of Ajuga iva (L.) Schreb. Copyright © 2020 Elsevier B.V. or its licensors or contributors. (2015) gave a concise total synthesis of 40 by constructing the stereocenters selectively using organo cuprates or tertiary carbon radical [246]. Cufod. Studies have shown antioxidant activity in a range of Stachys species and found a correlation with the concentration of polyphenols (Háznagy-Radnai et al 2006, Matkowski & Piotrowska 2006, Khanavi et al 2009) although Vundać et al (2007) argue that only the scavenging of free radicals is significant. In the same text appear an ointment for boils on the face and a poultice for neck and throat problems, while the herb taken beforehand prevents drunkenness. Additionally, terpenes from medicinal plants have the competency, within what could be termed a “protective window dose”, to protect neurons against β-amyloid peptide, glutamate, NO, oxygen and glucose deprivation and other toxic stimuli by hindering apoptosis by targeting numerous kinases, boosting the clearance of reactive oxygen species (ROS) and protecting the mitochondrial intergrity as described in this chapter. The leaves of the ajuga hold close together, which keeps them nice and short. From the structure activity analysis it was deduced that trans-decalin system incorporating C-3 olefinic bond accompanied by a butenolide ring in the side chain are essential features for the molecule to exhibit antidyslipidemic activity. These resistant insects have developed effective detoxification/inactivation mechanisms. Graeme Tobyn BA FHEA FNIMH, ... Margaret Whitelegg BA PhD FNIMH, in Medical Herbs, 2011. Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. It counters poison and the bites of snakes or any poisonous or rabid animal, when not only taken internally but also applied externally on a plaster. Until further research is forthcoming, this former panacea is probably better considered in practice as a tonic, not only of the nervous system but of the digestive system also, owing to its bitter, aromatic and spasmolytic qualities. (2000) reported the synthesis of enantiomer of clerodane diterpene via a furan photosensitized oxygenation reaction of (+)-hardwickiic acid [245]. The corolla may be dark blue, light blue, purple, or yellow and has a very short upper lip. Also, its absolute stereochemistry was established as 5R, 8R, 9R, 10R at four stereo-centers. Botany Ajuga integrifolia is a low herb covered with soft hairs, with erect, ascending stems which arise from the rootstock, branching usually diffusely from the base and measuring 10 to 20 centimeters in length. Ajuga (zhivuchka in Russian), a genus of plants of the family Labiatae. The record derives from WCSP (data supplied on 2012-03-23 ) which reports it as a synonym (record 5380) with original publication details: Pl. It presents gardeners with a tough decision in plant selection. Bulga Kuntze. More recently, Muller et al. Ajuga iva (L.,) Schreb., belongs to the Lamiaceae family and the genus of Ajuga (Israili and Lyoussi, 2009). With noun/verb tables for the different cases and tenses links to audio pronunciation and … Select a category... Ajuga Trustees Checklist Internet Governing Board Crowns Knowledge Bases Soil Fungi Water Supply Plant Leaves Nurseries Schools, Nursery Harmful Algal Bloom Flowers Nurseries, Hospital Cacao Dictionaries, Medical Dictionaries as Topic Dictionaries, Chemical Dictionary Terminology as Topic Dictionaries, Pharmaceutic Potentilla … This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models. We use cookies to help provide and enhance our service and tailor content and ads. Several species belonging to the Ajuga genus have been used in vitro and in vivo (Hsieh et al., 2014) to determine their hypoglycemic effects (A. decumbens, A. nipponensis, A. Pygmaea, A. Taiwanensis, A. Dictyocarpa). f. (2.3), and asiatic acid from Centella asiatica (L.) Urb. In the current review, we summarized A. iva botanical description, taxonomy, geographical distribution, traditional uses, phytochemical components, and biological properties. Later, Imamura et al. Diterpene 40 has been reported to show significant biological activities such as antifeedant, antimicrobial, antimalarial, and cytotoxicity against various human cancer cell lines [229,233,235–238]. =Ajuga remota var. In the search for new antimalarial drugs, ethnopharmacological sources should merit more attention. As secondary plant metabolites, phytoecdysteroids stimulate protein synthesis in plants, activate cell mitosis and possibly act as plant growth regulators. In this study, rats were divided into six groups: control normal group, diabetic control, diabetic rats treated with glibenclamide, diabetic rats treated with Ajuga iva (L.) Schreb. There are two pharmacological studies (Boudjelal et al., 2015; Chabane et al., 2013). They are perennial or annual herbs with opposite leaves. This proprietary Chinese formula is said to be composed of Panax notoginseng, San Yu Cao (Ajuga patantha), Dioscorea opposita, Chuan Shan Long (Dioscorea nipponica), Lao Guan Cao (Erodium stephanianum), Alpinia officinarum, Bai Niu Dan, and Dryobalanops aromatica (or Blumea balsamifera) (package label, 2005). The in vitro inhibition of one standard strain and 15 clinical isolates of Helicobacter pylori was tested using methanol and water extracts of 80 herbs, including 10 Stachys species wild collected in Greece. (family Cupressaceae Gray) (2.3), ajugalide D from Ajuga ciliata Bunge (2.3), carnosol from by Rosmarinus officinalis L. (2.3), triptolide from Tripterygium wilfordii Hook. crenata Hochst. It is also used for other indications, such as vasorelaxant (El-Hilaly et al., 2004), hypolipidemic (El-Hilaly et al., 2006), and anti-inflammatory, antifungal, antimicrobial, antifebrile, anthelmintic and antifeedant (Bondi et al., 2000). Definition of ajuga remota is አቆራራጭ፣ አርማጉሳ. Asiat. English Keyword (fr) Activité biologique Antipaludique Antiparasitaire In vitro Médecine traditionnelle Origine végétale Pharmacognosie Plante médicinale Plasmodium falciparum Ajuga remota Caesalpinia volkensii Caesalpiniaceae Kenya Angiospermae Apicomplexa Dicotyledones Labiatae Protozoa Spermatophyta Afrique Keyword (en) The decoction in old wine or vinegar stops toothache, if the mouth is regularly washed with it. Although several approaches have been reported for the synthesis of clerodane and related diterpenes [241–243], but only three describe the synthesis of 40. (1E,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4S*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4R*,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (3R*,4S*,5E,7Z)-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene, (1E,3R*,4R*,5E,7Z)-1,8-dibromo-3,4-dichloro-3,7-dimethylocta-1,5,7-triene, and (3R*,4S*)-3,4,6,7-tetrachloro-3,7-dimethylocten-1-ene showed greater cytotoxicity (IC50 of 6.6–9.9 µM) than the known cancer drug cisplatin (IC50 of 13 µM) in the cancer cell line [78]. (1830) =Ajuga bracteosa var. Betony in an eclegma, or thick syrup made from honey, sometimes conveyed to the mouth on a root of liquorice which is licked clean, and taken for 9 days eases a cough. Rar. =Ajuga remota var. Macer proposes the herb for all recent wounds and Miller adds the drawing of splinters to wound healing. Christophe Wiart PharmD, PhD, ACS, in Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases, 2014. Antonyms for ajugas. We use cookies to help provide and enhance our service and tailor content and ads. The relative configuration was assigned on the basis of the X-ray crystallographic analysis of its acetate derivative. Hagiwara et al. My herbal backyard system. Again these uses are variously transmitted down the centuries, until the external applications disappear by the 18th century. Table 4. Naringin was present in relatively high concentrations together with several flavone derivatives, as was also found in other studies (El-Hilaly and Lyoussi, 2002; Hsieh et al., 2014). And murine mesenchymal cell-line C3H10T1/2 been advocated for gastrointestinal, urinary, gynaecological, respiratory, musculoskeletal skin. L. donovani, inhibiting DNA topoisomerase I with the induction of apoptosis 239! It can heal sinuous and burrowing ulcers G. Wynn, Barbara J. 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