Past events. Oncode unites science, collaboration and valorization to create impact for patients. This type of DNA damage can have an endogenous cause, but it can also be caused by external influences, such as high dosages of chemotherapy in cancer. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (Figure 3). Mechanisms underlying cell-fate choice in early embryogenesis A major interest in the group is how gene-expression control is achieved in early embryogenesis. The ERC-starting grants are awarded to support up-and-coming research leaders who have recently established their own research team in Europe. ERC-starting grant for Marvin Tanenbaum and Jop Kind Marvin Tanenbaum and Jop Kind, both group leader at the Hubrecht Institute, are awarded an ERC-starting grant. Kind’s group previously developed advanced techniques with which they can study epigenetics in a single cell and match it with the cell’s choice of identity. Read more | 11 November . This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. Projects 1. 13:05. “That allows us to make a family tree of the various epigenetic stages that preceded the choice the cell eventually made. In particular, the group is interested in developing high-resolution single-cell techniques which can trace dynamic chromatin changes in living cells. Best Cities for Jobs 2020 NEW! Jop Kind, Group Leader at Hubrecht Institute and Oncode Investigator, will bring you up to speed with the basics of Single Cell Technology. Tumorigenesis involves the continuous selective adaptation of cells from healthy tissue, to adenoma, carcinoma and eventually metastasis. Dive into the research topics where Jop Kind is active. Save the date! Save the date for our Annual Conference! Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Jop Kind. He will zoom in on single-cell epigenomics and multi-omics. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. Additionally, they are planning to build so-called molecular time machines: by giving cells a mark in the earliest stages of embryonic development, the researchers can – once the cell has made its choice – trace the epigenetic status of the cells during the earlier stages of development. Sara is now working as a computational biologist in the lab of Jop Kind at the Hubrecht Institute (Netherlands). (Jop) Kind: Active at: The Netherlands Cancer Institute: Hubrecht Institute for Developmental Biology and Stem Cell Research: Email address: If you have any questions or problems regarding login, please contact narcis@dans.knaw.nl. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute, A major interest in the group is how gene-expression control is achieved in early embryogenesis. Kim L de Luca 1 , Jop Kind 2 ... 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Oncode is an independent institute dedicated to understanding cancer and translating research into practice. Merged citations. That way, we hope to better understand the relationship between epigenetics and the emergence of new cell types”, says Kind. Hubrecht Institute launches new website! He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. Miao-Ping Chien. Jop Kind obtained his PhD from the Radboud University in Nijmegen for his work on dosage compensation in the lab of Asifa Akhtar at the EMBL Heidelberg. 1 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Genome instability; UMC Utrecht. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. Cited by. The researchers in Kind’s group will use the ERC grant to further research when and how cells make these identity choices. ). Jop Kind. The Kind group uses a combination of single-cell genomics and microscopy methods to study the role of chromatin and epigenetics in gene-regulation control, with a focus on early mouse embryonic development and tumorigenesis. In addition, scDam&T allows determining cellular identity of cells in complex tissues -such as embryos or tumors- based on transcriptomics, in direct relation to their epigenetic regulatory landscapes (DamID). 13:05. In this conversation. Jop Kind Group. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research. 3 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Sort. j.kind@hubrecht.eu. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email communication@hubrecht.eu; Website http://www.hubrecht.eu/ Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. Since October 2014 he is Junior Group Leader at the Hubrecht Institute. We are employing scDam&T to obtain a better understanding of the epigenetic mechanisms underlying lineage decisions in early embryogenesis, to identify the epigenetic trajectories of single cells that acquire malignant identities in tumorigenesis and to obtain insight into the role of chromatin in DNA double-strand repair. ). The grant enables them to develop their own innovative line of research and set up their own research group. Wouter de Laat Group. Jop, now Group Leader at … Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. Projects 1. We are particularly interested in understanding the role of epigenetics and spatial genome organization in this process. Overview; Fingerprint; Network; Research Output (8) Similar Profiles (28) If you made any changes in Pure these will be visible here soon. Hubrecht Institute opens new laboratory building. Geert Kops Group. Puck Knipscheer is group leader at the Hubrecht Institute and Oncode investigator. ERC-starting grant for Marvin Tanenbaum and Jop Kind. Maria-Elena Torres-Padilla is group leader and director of the Institute of Epigenetics and Stem Cells (IES), Helmholtz Center Munich and professor of Stem cell biology at the Ludwig-Maximilians University. Award ceremony photo gallery. 12:35. 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. Hubrecht Institute, Developmental Biology and Stem Cell Research | 6,134 followers on LinkedIn. ); s.kefalopoulou@hubrecht.eu (S.K.) PhD. Their combined citations are counted only for the first article. Jobs. Electronic address: j.kind@hubrecht.eu. Molecular biologist dr. Jop Kind (1978) joined the Van Steensel lab as a postdoc after a highly successful PhD at the EMBL. The John Kendrew Young Scientist Award (JKA) was launched in 2007 as an initiative from the EMBL Pensioner’s Association to honour EMBL’s first Director General, Sir John Kendrew (1975-1982), and to support scientists in the early stages of their career. Jop Kind, group leader at the Hubrecht Institute, has been awarded a NWO Vidi-grant. Sort by citations Sort by year Sort by title. torres-padilla@helmholtz-muenchen.de. To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. That knowledge underlines the link between alcohol consumption and cancer. Technology development ‪Hubrecht Institute‬ - ‪Cited by 3,964‬ - ‪Single cell epigenomics‬ Citations per year. We employ our single-cell genomic methods to study cellular trajectories on route towards malignant metastatic identities. Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. See what employees say about what it's like to work at Hubrecht Institute. Year; Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. Network. The researchers want to know when and how cells in the early embryo ‘choose’ what type of cell they will become; whether they will for example become part of the skin or rather become part of the group of cells that forms the supporting embryonic tissue such as the placenta. Additionally, they will investigate whether there are other, currently unknown pathways involved in repairing ICLs. A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Hubrecht Institute. 3,331. The group focuses on a specific type of DNA damage called a DNA interstrand crosslink (ICL). 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